Dimerization extends Ï -conjugation of electron donor-acceptor structures leading to phototheranostic properties beyond the sum of two monomers

Li, Heng1; Li, Qing1; Gu, Ying2,3; Wang, Mengying1; Tan, Pu2,3; Wang, Hengtao2,3; Han, Liang2,3; Zhu, Yulin2,3; He, Feng2,3; Tian, Leilei1,4

2024-06-01

10.1002/agt2.528

AGGREGATE   影响因子和分区

2692-4560

Near-infrared (NIR)-II fluorescence imaging-guided photothermal therapy (PTT) has attracted great research interest, and constructing donor-acceptor (D-A) electronic configurations has become an established approach to lower bandgap and realize NIR-II emission. However, very few pi-conjugated phototheranostic agents can realize efficient NIR-II guided PTT using a clinically safe laser power density, implying that sufficient photothermal performance is still desired. In addition to the continuously refreshed photothermal conversion efficiency levels, the strategies that focus on enhancing light absorptivity have been rarely discussed and endow a new direction for enhancing PTT. Herein, a dimerization pi-extension strategy is raised to synthesize pi-conjugated dimers with A-D-A monomers. We observe that the light absorptivity (epsilon) of the dimers is strengthened three times owing to the enhanced electronic coupling effect as a result of the pi-conjugation extension, thereby surpassing the 2-fold increase in chromophore numbers from the monomer to dimers. Thanks to the enhancement in light absorption, the dimers could generate much more photothermal heat than the monomer in in vivo PTT treatments. Therefore, an efficient anti-tumor outcome has been fulfilled by using dimers under a low laser power (0.3 W/cm(2)). Moreover, the dimers with extended pi-conjugation structures become more favorable to the radiative excited state decay, thus exhibiting a distinguishing improvement in NIR-II imaging compared with monomer. Collectively, due to the improved light absorptivity, the dimers can gain superior NIR-II fluorescence brightness and photothermal performance over the recently reported material, which goes beyond the monomer in double doses for in vivo applications. All these results prove that dimerization is an effective strategy for designing high-performance phototheranostic materials.

dimerization NIR-II fluorescence imaging photothermal therapy safe intensity light pi-conjugation extension

ESCI

英语

第一 ; 通讯

Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Fundamental Research Programs["JCYJ20220530113612027","JCYJ20210324120010028"] ; Shenzhen Sci-Tech Fund[KQTD20170810111314625] ; null[51973089] ; null[22225504] ; null[21975115]

Chemistry ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary

WOS:001174459400001

WILEY

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Dept Mat Sci & Engn, 1088 Xueyuan Blvd, Shenzhen 518055, Guangdong, Peoples R China

Li, Heng,Li, Qing,Gu, Ying,et al. Dimerization extends Ï -conjugation of electron donor-acceptor structures leading to phototheranostic properties beyond the sum of two monomers[J]. AGGREGATE,2024,5(3).

Li, Heng.,Li, Qing.,Gu, Ying.,Wang, Mengying.,Tan, Pu.,...&Tian, Leilei.(2024).Dimerization extends Ï -conjugation of electron donor-acceptor structures leading to phototheranostic properties beyond the sum of two monomers.AGGREGATE,5(3).

Li, Heng,et al."Dimerization extends Ï -conjugation of electron donor-acceptor structures leading to phototheranostic properties beyond the sum of two monomers".AGGREGATE 5.3(2024).