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题名	LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis
作者	Yang, Lujie1 ; Yang, Qianting 2,3,4; Lin, Ling 5; Zhang, Chi1 ; Dong, Lingkai1 ; Gao, Xiang2,3,4 ; Zhang, Zheng 2,3,4 ; Zeng, Chen 1,6,7; Wang, Peng George1
通讯作者	Zhang, Zheng; Zeng, Chen; Wang, Peng George
发表日期	2024-04-18
DOI	10.1021/acs.analchem.3c04925
发表期刊	ANALYTICAL CHEMISTRY 影响因子和分区
ISSN	0003-2700
EISSN	1520-6882
卷号	96 期号:17
摘要	Glycosylation, a fundamental biological process, involves the attachment of glycans to proteins, lipids, and RNA, and it plays a crucial role in various biological pathways. It is of great significance to obtain the precise spatial distribution of glycosylation modifications at the cellular and tissue levels. Here, we introduce LectoScape, an innovative method enabling detailed imaging of tissue glycomes with up to 1 mu m resolution through image mass cytometry (IMC). This method utilizes 12 distinct, nonoverlapping lectins selected via microarray technology, enabling the multiplexed detection of a wide array of glycans. Furthermore, we developed an efficient labeling strategy for these lectins. Crucially, our approach facilitates the concurrent imaging of diverse glycan motifs, including N-glycan and O-glycan, surpassing the capabilities of existing technologies. Using LectoScape, we have successfully delineated unique glycan structures in various cell types, enhancing our understanding of the glycan distribution across human tissues. Our method has identified specific glycan markers, such as alpha 2,3-sialylated Gal beta 1, 3GalNAc in O-glycan, and terminal GalNAc, as diagnostic indicators for cervical intraepithelial neoplasia. This highlights the potential of LectoScape in cancer diagnostics through the detection of abnormal glycosylation patterns.
相关链接	[来源记录]
收录类别	SCI
语种	英语
重要成果	NI期刊
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[KQTD20200909113758004] ; Shenzhen Science and Technology Program[2022B1111050001] ; Key-Area Research and Development Program of GuangDong Province[22107044] ; National Natural Science Foundation of China[20210617141509001]
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
WOS记录号	WOS:001242092200001
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://kc.sustech.edu.cn/handle/2SGJ60CL/788163
专题	南方科技大学医学院_药理学系南方科技大学医学院南方科技大学第一附属医院南方科技大学第二附属医院生命科学学院_前沿生物技术研究院
作者单位	1.Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen 518055, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Inst Hepatol, Natl Clin Res Ctr Infect Dis, Shenzhen 518020, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen 518020, Guangdong, Peoples R China 4.Shenzhen Clin Res Ctr TB, Shenzhen 518020, Guangdong, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China 6.Southern Univ Sci & Technol, Inst Adv Biotechnol, Shenzhen 518055, Guangdong, Peoples R China 7.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Guangdong, Peoples R China
第一作者单位	药理学系; 南方科技大学医学院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院; 南方科技大学医学院; 药理学系; 前沿生物技术研究院
第一作者的第一单位	药理学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Yang, Lujie,Yang, Qianting,Lin, Ling,et al. LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis[J]. ANALYTICAL CHEMISTRY,2024,96(17).
APA	Yang, Lujie.,Yang, Qianting.,Lin, Ling.,Zhang, Chi.,Dong, Lingkai.,...&Wang, Peng George.(2024).LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis.ANALYTICAL CHEMISTRY,96(17).
MLA	Yang, Lujie,et al."LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis".ANALYTICAL CHEMISTRY 96.17(2024).