Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging

Zhang，Zhe1,2; Fang，Xiaofeng1; Liu，Zhihe1; Liu，Haichao2; Chen，Dandan1; He，Shuqing1; Zheng，Jie2; Yang，Bing2; Qin，Weiping2; Zhang，Xuanjun3; Wu，Changfeng1

2020-02-24

10.1002/anie.201914397

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Fluorescence probes in the NIR-IIa region show drastically improved imaging owing to the reduced photon scattering and autofluorescence in biological tissues. Now, NIR-IIa polymer dots (Pdots) are developed with a dual fluorescence enhancement mechanism. First, the aggregation induced emission of phenothiazine was used to reduce the nonradiative decay pathways of the polymers in condensed states. Second, fluorescence quenching was minimized by different levels of steric hindrance to further boost the fluorescence. The resulting Pdots displayed a fluorescence QY of ca. 1.7 % in aqueous solution, suggesting an enhancement of ca. 21 times in comparison with the original polymer in tetrahydrofuran (THF) solution. Small-animal imaging by using the NIR-IIa Pdots exhibited a remarkable improvement in penetration depth and signal to background ratio, as confirmed by through-skull and through-scalp fluorescent imaging of the cerebral vasculature of live mice.

aggregation-induced emission molecular engineering NIR-II fluorescence imaging polymer dots semiconducting polymers

SCI ; EI ; IC

英语

NI期刊 ; NI论文 ; ESI高被引

第一 ; 通讯

[JCYJ20170307110157501] ; National Natural Science Foundation of China[81771930] ; National Natural Science Foundation of China[]

Chemistry

Chemistry, Multidisciplinary

WOS:000508312000001

Wiley-VCH Verlag

20200508111512

Brain mapping ; Infrared devices ; Mammals ; Organic solvents ; Polymers ; Quenching ; Semiconducting polymers

Heat Treatment Processes:537.1 ; Semiconducting Materials:712.1 ; Imaging Techniques:746 ; Chemical Agents and Basic Industrial Chemicals:803 ; Polymeric Materials:815.1

CHEMISTRY

2-s2.0-85078653917

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.State Key Laboratory of Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Changchun,Jilin,130012,China
3.Cancer Centre and Centre of Reproduction,Development and Aging,Faculty of Health Science,University of Macau,Taipa,999078,Macao

Zhang，Zhe,Fang，Xiaofeng,Liu，Zhihe,et al. Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(9):3691-3698.

Zhang，Zhe.,Fang，Xiaofeng.,Liu，Zhihe.,Liu，Haichao.,Chen，Dandan.,...&Wu，Changfeng.(2020).Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(9),3691-3698.

Zhang，Zhe,et al."Semiconducting Polymer Dots with Dual-Enhanced NIR-IIa Fluorescence for Through-Skull Mouse-Brain Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.9(2020):3691-3698.