Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes

Tran，Paul M.H.1,2; Dong，Fran3; Kim，Eileen1; Richardson，Katherine P.1; Tran，Lynn K.H.1; Waugh，Kathleen3; Hopkins，Diane1; Cummings，Richard D.4; Wang，Peng George5; Rewers，Marian J.3; She，Jin Xiong1; Purohit，Sharad1,6,7

2022-12-01

10.1038/s41467-022-34341-2

Nature Communications   影响因子和分区

2041-1723

Type 1 diabetes (T1D) is an autoimmune disease, characterized by the presence of autoantibodies to protein and non-protein antigens. Here we report the identification of specific anti-carbohydrate antibodies (ACAs) that are associated with pathogenesis and progression to T1D. We compare circulatory levels of ACAs against 202 glycans in a cross-sectional cohort of T1D patients (n = 278) and healthy controls (n = 298), as well as in a longitudinal cohort (n = 112). We identify 11 clusters of ACAs associated with glycan function class. Clusters enriched for aminoglycosides, blood group A and B antigens, glycolipids, ganglio-series, and O-linked glycans are associated with progression to T1D. ACAs against gentamicin and its related structures, G418 and sisomicin, are also associated with islet autoimmunity. ACAs improve discrimination of T1D status of individuals over a model with only clinical variables and are potential biomarkers for T1D.

SCI

英语

NI期刊 ; NI论文

其他

Leona M. and Harry B. Helmsley Charitable Trust[G-1901-03687];Division of Cancer Epidemiology and Genetics, National Cancer Institute[R21CA199868];Division of Cancer Epidemiology and Genetics, National Cancer Institute[U01CA221242];

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000877942800001

NATURE PORTFOLIO

2-s2.0-85140936101

Scopus

1.Center for Biotechnology and Genomic Medicine,Medical College of Georgia,Augusta University,Augusta,1120 15th Street,30912,United States
2.Department of Internal Medicine,Yale School of Medicine,New Haven,CT06510,United States
3.Barbara Davis Center for Diabetes,University of Colorado Denver,Mail Stop A-140,Aurora,1775 Aurora Court,80045,United States
4.Department of Surgery,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,02115,United States
5.School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
6.Department of Obstetrics and Gynecology,Medical College of Georgia,Augusta University,Augusta,1120 15th Street,30912,United States
7.Department of Undergraduate Health Professionals,College of Allied Health Sciences Augusta University,Augusta,1120 15th Street,30912,United States

Tran，Paul M.H.,Dong，Fran,Kim，Eileen,et al. Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes[J]. Nature Communications,2022,13(1).

Tran，Paul M.H..,Dong，Fran.,Kim，Eileen.,Richardson，Katherine P..,Tran，Lynn K.H..,...&Purohit，Sharad.(2022).Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes.Nature Communications,13(1).

Tran，Paul M.H.,et al."Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes".Nature Communications 13.1(2022).