A Facile and Mild Alkylation Protocol of NH-Diphenyl Sulfondiimines

Xu，Zeyu; Su，Shuaisong; Li，Xue; Jia，Tiezheng

2022

10.1055/a-1946-6522

SYNLETT   影响因子和分区

0936-5214

1437-2096

As a promising pharmacophore, sulfondiimines have drawn increasing attention in recent years, but their uptake in medicinal chemistry is jeopardized by the scarcity of related transformations. Herein, we report a facile and mild N-alkylation protocol of NH-diphenyl sulfondiimines with alkyl halides to prepare a myriad of N-alkylated diphenyl sulfondiimines. Owing to air atmosphere, room temperature, as well as mild reaction conditions, this protocol has exhibited great potential in organic synthesis and medicinal chemistry by the late-stage functionalization of natural products.

alkyl bromides alkylation functional group tolerance mild Sulfondiimines

SCI ; IC ; CCR

英语

第一 ; 通讯

Natural Science Foundation of Guangdong Province[2022A1515011770] ; Guangdong-Joint Foundation of Shenzhen[2021B1515120046] ; Shenzhen Nobel Prize Scientists Laboratory Project[C17783101] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]

Chemistry

Chemistry, Organic

WOS:000868109500003

GEORG THIEME VERLAG KG

CHEMISTRY

2-s2.0-85139180391

Scopus

Chemistry,Southern University of Science and Technology,Shenzhen,China

Xu，Zeyu,Su，Shuaisong,Li，Xue,et al. A Facile and Mild Alkylation Protocol of NH-Diphenyl Sulfondiimines[J]. SYNLETT,2022,34(05).

Xu，Zeyu,Su，Shuaisong,Li，Xue,&Jia，Tiezheng.(2022).A Facile and Mild Alkylation Protocol of NH-Diphenyl Sulfondiimines.SYNLETT,34(05).

Xu，Zeyu,et al."A Facile and Mild Alkylation Protocol of NH-Diphenyl Sulfondiimines".SYNLETT 34.05(2022).