| 题名 | Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted beta-acetoxy-alpha-enamido esters and efficient synthesis of droxidopa |
| 作者 | |
| 通讯作者 | Lv, Hui; Zhang, Xumu |
| 发表日期 | 2017-07-25
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| DOI | |
| 发表期刊 | |
| ISSN | 1359-7345
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| EISSN | 1364-548X
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| 卷号 | 53期号:58页码:8136-8139 |
| 摘要 | A rhodium-catalyzed asymmetric hydrogenation of challenging tetrasubstituted beta-acetoxy-alpha-enamido esters was developed, giving chiral beta-acetoxy-alpha-amido esters in high yields with excellent enantio-selectivities (up to >99% ee). The products could be easily transformed to beta-hydroxy-alpha-amino acid derivatives which are valuable chiral building blocks and a novel route for the synthesis of droxidopa was also developed. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI期刊
; NI期刊
; NI论文
|
| 学校署名 | 通讯
|
| 资助项目 | Important Sci-Tech Innovative Project of Hubei Province[2015ACA058]
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| WOS研究方向 | Chemistry
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| WOS类目 | Chemistry, Multidisciplinary
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| WOS记录号 | WOS:000405679100006
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| 出版者 | |
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：19
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/28777 |
| 专题 | 理学院_化学系 |
| 作者单位 | 1.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 3.South Univ Sci & Technol China, Dept Chem, Shenzhen 518000, Peoples R China |
| 通讯作者单位 | 化学系 |
| 推荐引用方式 GB/T 7714 |
Guan, Yu-Qing,Gao, Min,Deng, Xu,et al. Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted beta-acetoxy-alpha-enamido esters and efficient synthesis of droxidopa[J]. CHEMICAL COMMUNICATIONS,2017,53(58):8136-8139.
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| APA |
Guan, Yu-Qing,Gao, Min,Deng, Xu,Lv, Hui,&Zhang, Xumu.(2017).Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted beta-acetoxy-alpha-enamido esters and efficient synthesis of droxidopa.CHEMICAL COMMUNICATIONS,53(58),8136-8139.
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| MLA |
Guan, Yu-Qing,et al."Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted beta-acetoxy-alpha-enamido esters and efficient synthesis of droxidopa".CHEMICAL COMMUNICATIONS 53.58(2017):8136-8139.
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| c7cc03902f.pdf（1548KB） | -- | -- | 限制开放 | -- | ||
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