Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands

Zhang, Jiangjiang; Huang, Zhentao; Xie, Yangzhouyun; Jiang, Xingyu

2021-12-01

10.1039/d1sc05933e

Chemical Science   影响因子和分区

2041-6520

2041-6539

Nanozymes have broad applications in theranostics and point-of-care tests. To enhance the catalytic activity of nanozymes, the conventional strategy is doping metals to form highly active nanoalloys. However, high-quality and stable nanoalloys are hard to synthesize. Ligand modification is a powerful strategy to achieve chemoselectivity or bioactivity by changing the surface chemistry. Here, we explore different ligands to enhance the catalytic activity of nanozymes, e.g., gold nanoparticles (AuNPs). We systematically studied the impacts on the enzymatic activity of AuNPs by ligand engineering of surface chemistry (charge, group, and surface distance). Our work established critical guidelines for surface modification of nanozymes. The amine group favors higher activity of AuNPs than other groups. The flexible amine-rich ligand enhances the catalytic activity of AuNPs in contrast to other ligands and unmodified AuNPs. Using a proof-of-concept model, we screened many candidate ligands to obtain polyamine-AuNPs, which have strongly enhanced peroxidase-like activity and 100 times enhanced sensitivity compared to unmodified AuNPs. The strategy of enhancing the catalytic activity of AuNPs using ligands will facilitate the catalysis-related applications of nanozymes in biology and diagnostics.

SCI ; EI

英语

NI期刊 ; NI论文

第一 ; 通讯

National Natural Science Foundation of China[22104049,22104050,21535001,81730051] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Key R&D Program of China[2018YFA0902600] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Chemistry

Chemistry, Multidisciplinary

WOS:000741521300001

ROYAL SOC CHEMISTRY

20220511564009

Amines ; Catalyst activity ; Fiber optic sensors ; Gold nanoparticles ; Metal nanoparticles ; Surface chemistry

Fiber Optics:741.1.2 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804 ; Organic Compounds:804.1

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Zhang, Jiangjiang,Huang, Zhentao,Xie, Yangzhouyun,et al. Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands[J]. Chemical Science,2021,13:1080-1087.

Zhang, Jiangjiang,Huang, Zhentao,Xie, Yangzhouyun,&Jiang, Xingyu.(2021).Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands.Chemical Science,13,1080-1087.

Zhang, Jiangjiang,et al."Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands".Chemical Science 13(2021):1080-1087.