Barcoded point-of-care bioassays

Yang, Mingzhu1; Liu, Yong1,2; Jiang, Xingyu1,2,3

2019-02-04

10.1039/c8cs00303c

CHEMICAL SOCIETY REVIEWS   影响因子和分区

0306-0012

1460-4744

Barcode technology can deliver batched information for patient healthcare. For clinical examinations, barcodes serve as reporters for labeling multiple targets, and meanwhile, facilitate improved sensitivity and specificity, thus enabling barcode as a promising alternative to traditional labels for biomarker identification and signal amplification. However, faced with the stringent claims of point-of-care (POC) bioassays, efforts are needed to advance current technologies toward rapidity, robustness, affordability, and user-friendliness. In the past decades, chemists have succeeded in delicate fabrication of the barcode libraries for encoding. Nevertheless, the decoding technologies remain poorly discussed, especially simplified decoding strategies for POC bioassays. Recent emergence of portable cartridges and miniaturized signal-recording devices has brought a promise to merge barcodes-assisted bioassay with POC testing (POCT). This review provides a comprehensive summary on barcode encoding and decoding, with emphasis on their potential use in POCT, facilitated by improved manufacturing and portable devices. Future directions of barcoded bioassays for POCT and current challenges are also presented. We anticipate that this review will be beneficial to promoting barcodes toward broad applications.

SCI ; EI

英语

通讯

National Science Foundation of China[81361140345] ; National Science Foundation of China[51373043] ; National Science Foundation of China[21535001] ; National Science Foundation of China[81730051]

Chemistry

Chemistry, Multidisciplinary

WOS:000457793900004

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Beijing Engn Res Ctr BioNanotechnol, CAS Ctr Excellence Nanosci, Natl Ctr NanoSci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China

Yang, Mingzhu,Liu, Yong,Jiang, Xingyu. Barcoded point-of-care bioassays[J]. CHEMICAL SOCIETY REVIEWS,2019,48(3):850-884.

Yang, Mingzhu,Liu, Yong,&Jiang, Xingyu.(2019).Barcoded point-of-care bioassays.CHEMICAL SOCIETY REVIEWS,48(3),850-884.

Yang, Mingzhu,et al."Barcoded point-of-care bioassays".CHEMICAL SOCIETY REVIEWS 48.3(2019):850-884.