| 题名 | Delivery of CRISPR/Cas9 by Novel Strategies for Gene Therapy |
| 作者 | |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu |
| 发表日期 | 2019-03
|
| DOI | |
| 发表期刊 | |
| ISSN | 1439-4227
|
| EISSN | 1439-7633
|
| 卷号 | 20期号:5页码:634-643 |
| 摘要 | Precise editing of the genome of a living body is a goal pursued by scientists in many fields. In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-associated) genome-editing systems have become a revolutionary toolbox for gene editing across various species. However, the low transfection efficiency of the CRISPR/Cas9 system to mammalian cells in vitro and in vivo is a big obstacle hindering wide and deep application. In this review, recently developed delivery strategies for various CRISPR/Cas9 formulations and their applications in treating gene-related diseases are briefly summarized. This review should inspire others to explore more efficient strategies for CRISPR system delivery and gene therapy. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | National Nature Science Foundation of China[31470911]
; National Nature Science Foundation of China[81673039]
; National Nature Science Foundation of China[21535001]
; National Nature Science Foundation of China[81730051]
; National Nature Science Foundation of China[21761142006]
; National Nature Science Foundation of China[81671784]
; National Nature Science Foundation of China[21505027]
|
| WOS研究方向 | Biochemistry & Molecular Biology
; Pharmacology & Pharmacy
|
| WOS类目 | Biochemistry & Molecular Biology
; Chemistry, Medicinal
|
| WOS记录号 | WOS:000461672200002
|
| 出版者 | |
| ESI学科分类 | BIOLOGY & BIOCHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：45
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/26359 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Harbin Inst Technol, Sch Life Sci & Technol, 2 Yikuang Rd, Harbin 150001, Heilongjiang, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 3.Jinan Univ, Inst Biomed Engn, 601 West Huangpu Ave, Guangzhou 510632, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China |
| 通讯作者单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Wang, Le,Zheng, Wenfu,Liu, Shaoqin,et al. Delivery of CRISPR/Cas9 by Novel Strategies for Gene Therapy[J]. CHEMBIOCHEM,2019,20(5):634-643.
|
| APA |
Wang, Le,Zheng, Wenfu,Liu, Shaoqin,Li, Bing,&Jiang, Xingyu.(2019).Delivery of CRISPR/Cas9 by Novel Strategies for Gene Therapy.CHEMBIOCHEM,20(5),634-643.
|
| MLA |
Wang, Le,et al."Delivery of CRISPR/Cas9 by Novel Strategies for Gene Therapy".CHEMBIOCHEM 20.5(2019):634-643.
|
| 条目包含的文件 | 条目无相关文件。 | |||||
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