Cell-Based Assays on Microfluidics for Drug Screening

Liu, Xiaoyan1,2,3,5; Zheng, Wenfu1,2,5; Jiang, Xingyu1,2,4,5

2019-06

10.1021/acssensors.9b00479

ACS Sensors   影响因子和分区

2379-3694

Microfluidics is an appealing platform for drug screening and discovery. Compared with the conventional drug screening methods based on Petri dishes and experimental animals, microfluidic devices have many advantages including miniaturized size, ease-to-use, high sensitivity, and high throughput. More importantly, bioassays on microfluidics can avoid ethical issues which can be a big obstacle hindering the performance of the experiments on animals or human being. Furthermore, three-dimensional (3D) microchips can recapitulate various biochemical and biophysical conditions in vivo and mimic the natural microenvironment of the tissues/organs, providing versatile in vitro models for biomedical applications. In this Perspective, we will focus on the cell-based microfluidic assays for drug screening. Meanwhile, we also propose potential solutions for the difficulties in this field and discuss the prospects of microfluidics-based technologies for drug screening.

microfluidics drug screening high-throughput biomimetics cell assay

SCI ; EI

英语

通讯

Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Chinese Academy of Sciences[121D11KYSB20170026]

Chemistry ; Science & Technology - Other Topics

Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology

WOS:000473827800003

AMER CHEMICAL SOC

20192407032069

Animals ; Biomimetics ; Medical applications ; Three dimensional computer graphics

Biotechnology:461.8 ; Microfluidics:632.5.1 ; Data Processing and Image Processing:723.2

Web of Science

1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
2.Natl Ctr NanoSci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
5.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China

Liu, Xiaoyan,Zheng, Wenfu,Jiang, Xingyu. Cell-Based Assays on Microfluidics for Drug Screening[J]. ACS Sensors,2019,4(6):1465-1475.

Liu, Xiaoyan,Zheng, Wenfu,&Jiang, Xingyu.(2019).Cell-Based Assays on Microfluidics for Drug Screening.ACS Sensors,4(6),1465-1475.

Liu, Xiaoyan,et al."Cell-Based Assays on Microfluidics for Drug Screening".ACS Sensors 4.6(2019):1465-1475.