A hinge-based aligner for fast, large-scale assembly of microfluidic chips

Mou, Lei1,2,3; Hu, Binfeng1,2,3; Zhang, Jiangjiang1,2,3; Jiang, Xingyu1,2,3,4,5

2019-09

10.1007/s10544-019-0404-y

BIOMEDICAL MICRODEVICES   影响因子和分区

1387-2176

1572-8781

Microfluidics has shown its vitality in scientific research. But the lack of fast and straightforward approaches for aligning chip and easy-to-control on-chip valve still prevent microfluidic chips from becoming powerful commercial products. This work presents an aligner based on hinge structures, which we call a hinge aligner, for aligning microfluidic chips. Two flat chip holders are connected by a connecting rod so that the chip holders can rotate relative to each other along the connecting rod, in the way a hinge works. The two chip holders contain pre-designed recesses for placing two chips which can align chips with 20 mu m resolution. Meanwhile, with this hinge aligner, we can easily implement a fully sealed on-chip valve, which can prevent aqueous liquids from leaking even at 80 degrees C for 30min. The real immunoassay result shows aligned microfluidic chips can detect protein with improved reproducibility in both high and low concentration of biomarkers.

Microfluidics Immunoassay Chip aligner POCT

SCI ; EI

英语

通讯

Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Chinese Academy of Sciences[121D11KYSB20170026] ; Chinese Academy of Sciences[XDA16020902]

Engineering ; Science & Technology - Other Topics

Engineering, Biomedical ; Nanoscience & Nanotechnology

WOS:000474371300004

SPRINGER

20192907185414

Connecting rods ; Fluidic devices ; Immunology

Immunology:461.9.1 ; Hydraulic Equipment and Machinery:632.2 ; Microfluidics:632.5.1

CLINICAL MEDICINE

Web of Science

1.Chinese Acad Sci, Natl Ctr NanoSci & Technol, Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Natl Ctr NanoSci & Technol, Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China
5.Guangzhou Med Univ, Affiliated Hosp 3, 63 Duobao Rd, Guangzhou 510150, Guangdong, Peoples R China

Mou, Lei,Hu, Binfeng,Zhang, Jiangjiang,et al. A hinge-based aligner for fast, large-scale assembly of microfluidic chips[J]. BIOMEDICAL MICRODEVICES,2019,21(3).

Mou, Lei,Hu, Binfeng,Zhang, Jiangjiang,&Jiang, Xingyu.(2019).A hinge-based aligner for fast, large-scale assembly of microfluidic chips.BIOMEDICAL MICRODEVICES,21(3).

Mou, Lei,et al."A hinge-based aligner for fast, large-scale assembly of microfluidic chips".BIOMEDICAL MICRODEVICES 21.3(2019).