NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles

Chen, Dandan; Liu, Ye; Zhang, Zhe; Liu, Zhihe; Fang, Xiaofeng; He, Shuqing; Wu, Changfeng

2021-01-13

10.1021/acs.nanolett.0c04543

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

The concept that systemically administered nanoparticles are highly accumulated into the liver, spleen and kidney is a central paradigm in the field of nanomedicine. Here, we report that bone is an important organ for retention of small polymer nanoparticles using in vivo fluorescence imaging in the second near-infrared (NIR-II) window. We prepared different sized polymer nanoparticles with both visible and NIR-II fluorescence. NIR-II imaging reveals that the behavior of nanoparticle distribution in bone was largely dependent on the particle size. Small polymer nanoparticles of similar to 15 nm diameter showed fast accumulation and long-term retention in bone, while the nanoparticles larger than similar to 25 nm were dominantly distributed in liver. Confocal microscopy of bone sections indicated that the nanoparticles were largely distributed in the endothelial cells of sinusoidal vessels in bone marrow. The study provides promising opportunities for bone imaging and treatment of bone-related disease.

nanoparticles NIR-II fluorescence bone imaging sinusoidal endothelium cells

SCI ; EI

英语

NI期刊 ; NI论文

第一 ; 通讯

National Key R&D Program of China["2020YFA0909000","2018YFB0407200"] ; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625] ; National Natural Science Foundation of China[81771930]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000611082000108

AMER CHEMICAL SOC

20210209762793

Endothelial cells ; Infrared devices ; Medical nanotechnology ; Nanoparticles ; Particle size ; Polymers

Biology:461.9 ; Nanotechnology:761 ; Polymeric Materials:815.1 ; Solid State Physics:933

MATERIALS SCIENCE

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Chen, Dandan,Liu, Ye,Zhang, Zhe,et al. NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles[J]. NANO LETTERS,2021,21(1):798-805.

Chen, Dandan.,Liu, Ye.,Zhang, Zhe.,Liu, Zhihe.,Fang, Xiaofeng.,...&Wu, Changfeng.(2021).NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles.NANO LETTERS,21(1),798-805.

Chen, Dandan,et al."NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles".NANO LETTERS 21.1(2021):798-805.