Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy

Men，Xiaoju1; Chen，Haobin2; Sun，Chen3; Liu，Yubin1; Wang，Ruibing3; Zhang，Xuanjun1; Wu，Changfeng2; Yuan，Zhen1

2020-11-18

10.1021/acsami.0c13252

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Precision delivery of theranostic agents to the tumor site is essential to improve their diagnostic and therapeutic efficacy and concurrently minimize adverse effects during treatment. In this study, a novel concept of near-infrared (NIR) light activation of conjugated polymer dots (Pdots) at thermosensitive hydrogel nanostructures is introduced for multimodal imaging-guided synergistic chemo-photothermal therapy. Interestingly, owing to the attractive photothermal conversion efficiency of Pdots, the Pdots@hydrogel as theranostic agents is able to undergo a controllable softening or melting state under the irradiation of NIR laser, resulting in light-triggered drug release in a controlled way and concurrently hydrogel degradation. Besides, the novel Pdots@hydrogel nanoplatform can serve as the theranostic agent for enhanced trimodal photoacoustic (PA)/computed tomography (CT)/fluorescence (FL) imaging-guided synergistic chemo-photothermal therapy of tumors. More importantly, the constructed intelligent nanocomposite Pdots@hydrogel exhibits excellent biodegradability, strong NIR absorption, bright PA/CT/FL signals, and superior tumor ablation effect. Therefore, the concept of a light-controlled multifunctional Pdots@hydrogel that integrates multiple diagnostic/therapeutic modalities into one nanoplatform can potentially be applied as a smart nanotheranostic agent to various perspectives of personalized nanomedicine.

semiconducting polymer nanoparticles multimode imaging photoacoustic imaging controlled drug release chemo-photothermal therapy

SCI ; EI

英语

其他

University of Macau in Macau["MYRG2019-00082-FHS","MYRG2018-00081-FHS"] ; Macau government["FDCT 0011/2018/A1","FDCT 025/2015/A1"] ; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625] ; National Natural Science Foundation of China[81771930]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000592923100004

AMER CHEMICAL SOC

20204909564311

Nanocomposites ; Tumors ; Targeted drug delivery ; Computerized tomography ; Conjugated polymers ; Controlled drug delivery ; Infrared devices ; Biodegradability ; Diagnosis ; Medical nanotechnology

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Computer Applications:723.5 ; Nanotechnology:761 ; Biochemistry:801.2 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Polymers:815.1.1 ; Solid State Physics:933

Web of Science

1.Faculty of Health Sciences,Center for Cognitive and Brain Sciences,University of Macau,Taipa,999708,Macao
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,999708,Macao

Men，Xiaoju,Chen，Haobin,Sun，Chen,et al. Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy[J]. ACS Applied Materials & Interfaces,2020,12(46):51174-51184.

Men，Xiaoju.,Chen，Haobin.,Sun，Chen.,Liu，Yubin.,Wang，Ruibing.,...&Yuan，Zhen.(2020).Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy.ACS Applied Materials & Interfaces,12(46),51174-51184.

Men，Xiaoju,et al."Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy".ACS Applied Materials & Interfaces 12.46(2020):51174-51184.