The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles

Wang, Le2,3; Li, Sixiang3; Yin, Jiaxiang1; Yang, Junchuan1; Li, Qizhen3; Zheng, Wenfu1; Liu, Shaoqin2; Jiang, Xingyu2,3

2020-07-08

10.1021/acs.nanolett.0c01196

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

With the widespread use of antibiotics, the number of complex infection cases caused by unknown pathogens is increasing and novel antibiotics with tunable antibacterial spectra and low toxicity are highly desirable. Herein, we report that, by selecting thiol or amine, two groups with different binding affinities with gold, as anchoring groups, phenylboronic acid can be decorated on gold nanoparticles (AuNPs) with different densities, which contributes to Gram-selective antibacterial activities of the AuNPs. The AuNPs modified with amine- or thiol-tethered phenylboronic acids specifically bind to lipopolysaccharide (LPS, Gram-negative) or lipoteichoic acid (LTA, Gram-positive), respectively. By modifying AuNPs with different ratios of thioland amine-tethered phenylboronic acids, the resulting AuNPs show potent and tunable antibacterial activity. The AuNP-based antibacterial agents with optional Gram selectivity are promising for applications in personalized therapy.

Gold nanoparticles Antibacterial Surface ligand Phenylboronic acid

SCI ; EI

英语

NI期刊 ; NI论文

通讯

National Key R&D Program of China[2018YFA0902600][2018ZX10731101001011][2017YFA0205901] ; National Natural Science Foundation of China[21535001][81730051][21761142006][81673039] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039][121D11KYSB20170026][XDA16020902] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000548893200045

AMER CHEMICAL SOC

20203008979638

Metal nanoparticles ; Fiber optic sensors ; Organic acids ; Antibiotics ; Binding energy

Medicine and Pharmacology:461.6 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Organic Compounds:804.1

MATERIALS SCIENCE

Web of Science

1.Natl Ctr Nanosci & Technol, GBA Res Innovat Inst Nanotechnol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Wang, Le,Li, Sixiang,Yin, Jiaxiang,et al. The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles[J]. NANO LETTERS,2020,20(7):5036-5042.

Wang, Le.,Li, Sixiang.,Yin, Jiaxiang.,Yang, Junchuan.,Li, Qizhen.,...&Jiang, Xingyu.(2020).The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles.NANO LETTERS,20(7),5036-5042.

Wang, Le,et al."The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles".NANO LETTERS 20.7(2020):5036-5042.