| 题名 | Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids |
| 作者 | |
| 通讯作者 | Jiang，Ru; Chen，Weiping; Zhang，Xumu |
| 发表日期 | 2020
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| DOI | |
| 发表期刊 | |
| ISSN | 1523-7060
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| EISSN | 1523-7052
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| 卷号 | 22期号:12页码:4812-4816 |
| 摘要 | The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodology was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen. |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI期刊
; NI论文
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| 学校署名 | 通讯
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| 资助项目 | National Natural Science Foundation of China[21272271][21472240]
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| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Organic
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| WOS记录号 | WOS:000543669800043
|
| 出版者 | |
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：9
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://kc.sustech.edu.cn/handle/2SGJ60CL/140351 |
| 专题 | 理学院_化学系 深圳格拉布斯研究院 |
| 作者单位 | 1.School of Pharmacy,Fourth Military Medical University,Xi'an,169 Changle West Road,710032,China 2.Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China |
| 通讯作者单位 | 化学系; 深圳格拉布斯研究院 |
| 推荐引用方式 GB/T 7714 |
Liu，Xian,Wen，Jialin,Yao，Lin,et al. Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids[J]. ORGANIC LETTERS,2020,22(12):4812-4816.
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| APA |
Liu，Xian.,Wen，Jialin.,Yao，Lin.,Nie，Huifang.,Jiang，Ru.,...&Zhang，Xumu.(2020).Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids.ORGANIC LETTERS,22(12),4812-4816.
|
| MLA |
Liu，Xian,et al."Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids".ORGANIC LETTERS 22.12(2020):4812-4816.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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