Synthesis of chiral a-substituted a-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation

Liu，Gongyi1; Zhang，Xianghe1; Wang，Heng2; Cong，Hengjiang1; Zhang，Xumu1,2; Dong，Xiu Qin1

2020-05-04

10.1039/d0cc01220c

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

Highly efficient Ni-catalyzed asymmetric hydrogenation of cyclicN-sulfonyl ketimino esters was, for the first time, successfully developed, providing various chiral a-monosubstituted a-amino acid derivatives with excellent results (97-99% yields, 90 to >99% ee). CyclicN-sulfonyl ketimines were also hydrogenated well to afford chiral amine derivatives with 98-99% yields and 97 to >99% ee. The gram-scale asymmetric hydrogenation was performed well with 85% yield and 99% ee using only 0.2 mol% catalyst.

SCI ; EI

英语

NI期刊 ; NI论文

通讯

WOS:000532243000013

20202008644008

Hydrogenation ; Amino acids

Chemical Reactions:802.2 ; Organic Compounds:804.1

CHEMISTRY

2-s2.0-85084272949

Scopus

1.Key Laboratory of Biomedical Polymers,Engineering Research Center of Organosilicon Compounds & Materials,Ministry of Education,College of Chemistry and Molecular Sciences,Suzhou Institute of Wuhan University,Wuhan University,Wuhan,430072,China
2.Shenzhen Grubbs Institute,Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China

Liu，Gongyi,Zhang，Xianghe,Wang，Heng,et al. Synthesis of chiral a-substituted a-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation[J]. CHEMICAL COMMUNICATIONS,2020,56(36):4934-4937.

Liu，Gongyi,Zhang，Xianghe,Wang，Heng,Cong，Hengjiang,Zhang，Xumu,&Dong，Xiu Qin.(2020).Synthesis of chiral a-substituted a-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation.CHEMICAL COMMUNICATIONS,56(36),4934-4937.

Liu，Gongyi,et al."Synthesis of chiral a-substituted a-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation".CHEMICAL COMMUNICATIONS 56.36(2020):4934-4937.