Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near-Infrared Photoacoustic Imaging and Photothermal Cancer Therapy

Men, Xiaoju1; Wang, Fei2; Chen, Haobin2; Liu, Yubin1; Men, Xiaoxiao2; Yuan, Ye3; Zhang, Zhe3; Gao, Duyang1; Wu, Changfeng2; Yuan, Zhen1

2020-04-27

10.1002/adfm.201909673

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Phototheranostic agents in the second near-infrared (NIR-II) window (1000-1700 nm) are emerging as a promising theranostic platform for precision medicine due to enhanced penetration depth and minimized tissue exposure. The development of metabolizable NIR-II nanoagents for imaging-guided therapy are essential for noninvasive disease diagnosis and precise ablation of tumors. Herein, metabolizable highly absorbing NIR-II conjugated polymer dots (Pdots) are reported for the first time for photoacoustic imaging guided photothermal therapy (PTT). The unique design of low-bandgap D-A pi-conjugated polymer (DPP-BTzTD) together with modified nanoreprecipitation conditions allows to fabricate NIR-II absorbing Pdots with ultrasmall (4 nm) particle size. Extensive experimental tests demonstrate that the constructed Pdots exhibit good biocompatibility, excellent photostability, bright photoacoustic signals, and high photothermal conversion efficiency (53%). In addition, upon tail-vein intravenous injection of tumor-bearing mice, Pdots also show high-efficient tumor ablation capability with rapid excretion from the body. In particular, both in vitro and in vivo assays indicate that the Pdots possess remarkable PTT performance under irradiation with a 1064 nm laser with 0.5 W cm(-2), which is much lower than its maximum permissible exposure limit of 1 W cm(-2). This pilot study thus paves a novel avenue for the development of organic semiconducting nanoagents for future clinical translation.

photoacoustic imaging photothermal therapy polymer dots second near-infrared window semiconducting polymers

SCI ; EI

英语

NI期刊 ; NI论文

其他

Shenzhen Science and Technology Innovation Commission[JCYJ20170307110157501]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000528635800001

WILEY-V C H VERLAG GMBH

20201908613204

Disease control ; Conjugated polymers ; Semiconducting polymers ; Diagnosis ; Particle size ; Infrared devices ; Mammals ; Ablation ; Biocompatibility ; Photoacoustic effect ; Diseases

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Heat Transfer:641.2 ; Semiconducting Materials:712.1 ; Light/Optics:741.1 ; Acoustic Waves:751.1 ; Organic Polymers:815.1.1

MATERIALS SCIENCE

Web of Science

1.Univ Macau, Fac Hlth Sci, Ctr Canc, Ctr Cognit & Brain Sci, Macau 999078, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Jilin Univ, State Key Lab Integrated Optoelect, Coll Elect Sci & Engn, Changchun 130012, Peoples R China

Men, Xiaoju,Wang, Fei,Chen, Haobin,et al. Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near-Infrared Photoacoustic Imaging and Photothermal Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2020,30(24).

Men, Xiaoju.,Wang, Fei.,Chen, Haobin.,Liu, Yubin.,Men, Xiaoxiao.,...&Yuan, Zhen.(2020).Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near-Infrared Photoacoustic Imaging and Photothermal Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,30(24).

Men, Xiaoju,et al."Ultrasmall Semiconducting Polymer Dots with Rapid Clearance for Second Near-Infrared Photoacoustic Imaging and Photothermal Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 30.24(2020).