Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms

Xie, Yangzhouyun1,2; Zheng, Wenfu2; Jiang, Xingyu1,2

2020

10.1021/acsami.9b21777

ACS Applied Materials and Interfaces   影响因子和分区

19448252

1944-8252

A bacterial biofilm is strongly associated with chronic infections and is difficult to be eradicated, posing serious threats to public health. Development of effective therapeutic strategies to prevent and control hospital-acquired infections via eradication of bacteria shielded by biofilms is challenging. Herein, we developed deoxyribonuclease (DNase)-functionalized gold nanoclusters (AuNCs) (DNase-AuNCs), which are capable of killing Gram-positive and Gram-negative bacteria, especially dispersing the surrounding biofilms. The DNase can break down the extracellular polymeric substance matrix to expose the defenseless bacteria to photothermal therapy (PTT) and photodynamic therapy (PDT) by DNase-AuNCs under 808 nm laser irradiation. The combination of enzymolysis, PDT, and PTT can effectively remove biofilms with a dispersion rate of up to 80% and kill ∼90% of the shielded bacteria. DNase-AuNCs exhibit an outstanding therapeutic effect in treating bacterial biofilm-coated orthodontic devices (Invisalign aligners), suggesting their potential applications in medical devices.
Copyright © 2020 American Chemical Society.

gold nanoclusters antibiofilm phototherapy enzymolysis near infrared light

SCI ; EI

英语

第一

[2017YFA0205901] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; National Natural Science Foundation of China[81673039]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000517360000008

American Chemical Society

20201108276248

Bacteria ; Biofilms ; Gold ; Health risks ; Infrared devices ; Nanoclusters ; Photodynamic therapy

Medicine and Pharmacology:461.6 ; Health Care:461.7 ; Biomaterials (including synthetics):462.5 ; Precious Metals:547.1 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

1.Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong; 518055, China
2.Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing; 100190, China

Xie, Yangzhouyun,Zheng, Wenfu,Jiang, Xingyu. Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms[J]. ACS Applied Materials and Interfaces,2020,12(8):9041-9049.

Xie, Yangzhouyun,Zheng, Wenfu,&Jiang, Xingyu.(2020).Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms.ACS Applied Materials and Interfaces,12(8),9041-9049.

Xie, Yangzhouyun,et al."Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms".ACS Applied Materials and Interfaces 12.8(2020):9041-9049.